Dimethyl Sulfoxide
Apexbio Technology LLC Fruquintinib(HMPL-013) 1194506-26-7 10mM (in 1mL DMSO)
Fruquintinib (HMPL-013 CAS 1194506-26-7) is a small molecule inhibitor targeting VEGFR family receptor tyrosine kinases (VEGFR1 VEGFR2 and VEGFR3) It demonstrates potent inhibitory activity with reported IC50 values of approximately 33 nM (VEGFR1) 35 nM (VEGFR2) and 0 5 nM (VEGFR3) Kinase selectivity screening indicates limited off-target effects against other kinases such as RET FGFR-1 and c-kit In preclinical tumor xenograft studies (e g gastric cancer BGC-823 model) significant tumor growth suppression ( 80%) was achieved at sustained therapeutic exposure Fruquintinib is currently under clinical investigation for cancer treatment based on its selective VEGFR pathway inhibition
Apexbio Technology LLC GSK-923295 1088965-37-0 10mM (in 1mL DMSO)
GSK-923295 (CAS 1088965-37-0) is a highly potent inhibitor targeting the centromere-associated protein E (CENP-E) a kinesin motor protein essential for proper chromosome alignment and progression from metaphase to anaphase during cell division By blocking microtubule-stimulated ATPase activity of CENP-E GSK-923295 stabilizes an ATP-bound intermediate resulting in significantly reduced enzymatic function (IC50 3 2 nM) In cellular models GSK-923295 induces mitotic arrest with morphological changes similar to CENP-E knockdown In mouse xenograft models using Colo205 colon carcinoma cells administration of GSK-923295 leads to tumor growth inhibition and increased apoptosis supporting its utility in cancer research
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide suitabl
Dimethyl sulfoxide (DMSO) is a polar organic solvent. DMSO activated by various electrophiles (oxalyl chloride) has been used to oxidize various alcohols (primary secondary allylic benzylic hindered and bicyclic). Carbonyl compounds are formed as reaction products. Due to its higher stability it has been proposed as an alternate solvent for methyl cellosolve for use in ninhydrin reaction.
Medchemexpress LLC HY-Y0320 200mL , Dimethyl sulfoxide CAS:67-68-5 Purity:>98%
HY-Y0320 200mL Dimethyl sulfoxide CAS: 67-68-5 Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves both polar and nonpolar compounds. Dimethyl sulfoxide has anti-freezing and bacteriostatic properties. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC GM 6001 142880-36-2 10mM (in 1mL DMSO)
GM 6001 (Ilomastat Galardin CAS 142880-36-2) is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) including MMP-1 -2 -3 -8 and -9 with reported Ki values of 0 4 nM 0 5 nM 27 nM 0 1 nM and 0 2 nM respectively MMPs participate in extracellular matrix remodeling and mediate signaling events induced by GPCR agonists through EGFR transactivation GM 6001 suppresses EGFR phosphorylation ERK activation and subsequent DNA synthesis induced by stimuli such as bombesin and lysophosphatidic acid (LPA) Additionally this compound has potential applications in cartilage research facilitating meniscal repair under inflammatory conditions by dampening IL-1-mediated MMP activity
Apexbio Technology LLC Lonidamine 50264-69-2 10mM (in 1mL DMSO)
Lonidamine (AF-1890) is a cell metabolism inhibitor targeting mitochondrial pyruvate carrier and hexokinase exhibiting inhibitory activity with a Ki value of approximately 2 5 M Through these targets it disrupts glycolytic metabolism by impairing aerobic glycolysis processes common in tumor cells Researchers utilize Lonidamine primarily to investigate metabolic pathways implicated in cancer cell energy production alterations in mitochondrial functions and related metabolic disorders Additionally Lonidamine is employed experimentally in studies examining mitochondrial dysfunction-associated conditions and inflammatory responses including pulmonary fibrosis
Apexbio Technology LLC GW9662(Synonyms: GW-9662, GW 9662, 2-Chloro-5-nitro-N-phenylbenzamide, PPAR gamma antagonist GW9662), 10mM (in 1mL DMSO), CAS: 22978-25-2.
GW9662 (CAS 22978-25-2) is an antagonist of peroxisome proliferator-activated receptor gamma (PPAR ) a nuclear receptor involved in various biological processes including tumor growth and inflammation GW9662 irreversibly blocks PPAR activity by covalently modifying cysteine residues at its ligand-binding site (IC50 3 3 M) In cellular assays GW9662 inhibits proliferation of breast cancer cell lines (MCF7 MDA-MB-231 MDA-MB-468 IC50 20 30 M) Additionally GW9662 reverses the protective impact of lipopolysaccharide on kidney ischemia/reperfusion injury demonstrating its utility for studying PPAR -mediated pathways in oncology and inflammation models
Apexbio Technology LLC Nepicastat (SYN-117) HCl 170151-24-3 10mM (in 1mL DMSO)
Nepicastat (SYN-117) HCl is a potent and selective inhibitor targeting dopamine -hydroxylase (DBH) an enzyme responsible for converting dopamine to norepinephrine in catecholamine biosynthesis pathways By inhibiting DBH activity Nepicastat decreases norepinephrine synthesis and concurrently elevates dopamine levels Preclinical studies conducted in animal models such as spontaneously hypertensive rats and canine models demonstrate a dose-dependent reduction of norepinephrine levels accompanied by elevation of dopamine concentration across central nervous system and cardiac tissues Nepicastat serves as a valuable research tool in investigating catecholamine homeostasis cardiovascular function sympathetic regulation and dopamine-mediated neurotransmission
Apexbio Technology LLC A66 1166227-08-2 10mM (in 1mL DMSO)
A66 (CAS 1166227-08-2) is a selective inhibitor of the p110 catalytic subunit of class I phosphatidylinositol-4 5-bisphosphate 3-kinase (PI3K) with an IC50 of 32 nM This compound specifically decreases phosphorylation of Akt/PKB and downstream S6K at Thr389 in various cell models including PIK3CA-mutant H1047R cell lines C2C12 myoblasts and 3T3-L1 adipocytes In animal studies A66 reduces tumor growth in xenograft models and improves insulin sensitivity under chronic metabolic stress highlighting its utility in research on PI3K signaling in cancer and metabolic disease
Apexbio Technology LLC Sephin1 13098-73-2 10mM (in 1mL DMSO)
Sephin1 (CAS 13098-73-2) is a selective inhibitor of PPP1R15A a regulatory subunit of protein phosphatase 1 involved in the regulation of stress-induced eIF2 dephosphorylation Under endoplasmic reticulum (ER) stress phosphorylated eIF2 attenuates protein synthesis preventing accumulation of misfolded proteins By inhibiting PPP1R15A Sephin1 sustains eIF2 phosphorylation extending translational attenuation during ER stress In cell assays Sephin1 selectively disrupts PPP1R15A-PP1c complexes without affecting PPP1R15B-mediated complexes In mouse models harboring misfolded protein mutations (e g MPZ or SOD1) Sephin1 administration mitigates molecular cellular and functional deficits thus relevant for proteostasis-related disease studies
Apexbio Technology LLC CO-1686 (AVL-301) 1374640-70-6 10mM (in 1mL DMSO)
CO-1686 (AVL-301 CAS 1374640-70-6) is an orally delivered irreversible small molecule inhibitor targeting mutated epidermal growth factor receptor (EGFR) It functions by forming a covalent bond at cysteine 797 in the ATP-binding domain of EGFR selectively inhibiting mutant variants such as L858R/T790M with reported IC50 values below 0 51 nM CO-1686 preferentially targets mutant EGFR over wild-type demonstrating approximately 22-fold selectivity Preclinical studies using non-small cell lung cancer (NSCLC) cell lines and xenograft models carrying EGFR mutations showed potent anti-proliferative and tumor regression effects Thus CO-1686 represents a valuable research tool in studying mutant EGFR-mediated oncogenesis
Selleck Chemical LLC Trametinib DMSO solvate S4484-1g
Trametinib DMSO solvate is a highly specific and potent MEK1/2 inhibitor with IC50 of 0 92 nM/1 8 nM in cell-free assay Trametinib activates autophagy and induces apoptosis