Dimethyl Sulfoxide
Apexbio Technology LLC c-Myc tag Peptide 2918768-02-0 10mM (in 1mL DMSO)
c-Myc tag peptide is a synthetic peptide with the amino acid sequence EQKLISEEDL corresponding to residues 410-419 at the C-terminal region of human c-Myc protein It serves as an epitope tag for recombinant protein expression enabling specific recognition and purification of fusion proteins using anti-c-Myc antibodies In immunoassays the peptide competitively binds to anti-c-Myc antibodies confirming antibody-antigen binding specificity and facilitating analysis of fusion proteins in Western blotting immunoprecipitation and immunofluorescence experiments c-Myc itself encodes a transcription factor regulating cellular processes such as proliferation growth apoptosis differentiation and stem-cell renewal pathways and is frequently overexpressed in cancers
Apexbio Technology LLC QNZ (EVP4593) 545380-34-5 10mM (in 1mL DMSO)
QNZ (EVP4593 CAS number 545380-34-5) is a quinazoline-derived small molecule inhibitor of the NF- B signaling pathway Originally identified using a luciferase reporter assay in human Jurkat T cells QNZ effectively suppresses PMA/PHA-induced NF- B transcriptional activation (IC50 11 nM) and TNF- production (IC50 7 nM) Additionally QNZ demonstrates anti-inflammatory properties reducing edema formation in a carrageenan-induced rat paw swelling model In Huntington s disease research QNZ improved motor performance in transgenic fly models without toxicity suggesting potential neuroprotective applications
Apexbio Technology LLC SL-327 305350-87-2 10mM (in 1mL DMSO)
SL-327 (CAS 305350-87-2) is a selective inhibitor targeting MEK1 and MEK2 kinases exhibiting IC50 values of 0 18 M and 0 22 M respectively MEK1/2 mediate the phosphorylation and activation of extracellular signal-regulated kinases (ERK) crucial components of the MAPK/ERK signaling pathway SL-327 treatment lowers phosphorylated ERK levels and subsequent activation of transcription factors including CREB Elk-1 and c-Fos influencing gene expression linked to synaptic plasticity In animal models SL-327 modulates drug-induced behaviors and neuronal plasticity processes making it a relevant molecular tool to investigate MAPK/ERK signaling pathways in neuroscience research
Apexbio Technology LLC Ezatiostat hydrochloride 286942-97-0 10mM (in 1mL DMSO)
Ezatiostat hydrochloride (CAS 286942-97-0) also known as TLK199 is a small-molecule inhibitor primarily targeting glutathione S-transferase (GST) specifically the GST P1-1 isoform GST P1-1 typically suppresses the Jun N-terminal kinase (JNK) signaling pathway thus Ezatiostat hydrochloride through GST P1-1 inhibition activates JNK signaling In preclinical research this activation has been associated with increased proliferation maturation and differentiation of hematopoietic precursor cells Additionally Ezatiostat hydrochloride induces growth arrest and apoptosis in human leukemia HL-60 cells (CC50 approximately 6-17 M) It holds potential for treating cytopenias and hematological disorders
Apexbio Technology LLC Tetracaine HCl 136-47-0 10mM (in 1mL DMSO)
Tetracaine hydrochloride (CAS 136-47-0) is a small molecule local anesthetic commonly used in biomedical research It acts through allosteric modulation of ion channel function specifically inhibiting calcium channels and effectively suppressing voltage-dependent calcium release from the sarcoplasmic reticulum Due to its ability to regulate calcium channel activity tetracaine HCl serves as an important investigative tool in studies exploring calcium signaling pathways muscle physiology and neuronal excitability
Apexbio Technology LLC Quercetin(Synonyms: Sophoretin, Meletin, Quercetine, 3,3',4',5,7-Pentahydroxyflavone, Quercetol, Xanthaurine), 10mM (in 1mL DMSO), CAS: 117-39-5.
Quercetin (CAS 117-39-5) is a dietary flavonoid widely found in fruits vegetables nuts tea and red wine exhibiting notable antineoplastic and anti-inflammatory effects It functions primarily as a potent inhibitor of intracellular signaling kinases including PI3K and NF- B and moderately inhibits Akt1/2 with weaker effects on PKC p38 and ERK1/2 pathways Moreover quercetin can elevate cytosolic Ca levels disrupt mitochondrial membrane potential induce cytochrome c release and activate caspases (3 8 and 9) thereby promoting apoptosis through mitochondrial pathways It also affects cell cycle progression and apoptosis via stabilizing and phosphorylating p53 Thus quercetin serves as a valuable tool in cancer research providing insights into chemoprevention mechanisms and therapeutic potentials
Apexbio Technology LLC Cilengitide 188968-51-6 10mM (in 1mL DMSO)
Cilengitide (CAS 188968-51-6) is a cyclic RGD pentapeptide [Arg-Gly-Asp-DPhe-(NMeVal)] that acts as an inhibitor of integrins v 3 and v 5 These integrins are transmembrane receptors mediating cellular processes such as adhesion migration angiogenesis and invasion Cilengitide binds directly to v 3 integrin receptors inhibiting integrin-mediated activities with an IC50 of 250 nM In in vitro assays cilengitide dose-dependently reduces proliferation and adhesion of endothelial progenitor cells In vivo studies showed that cilengitide administration significantly lowered osteolytic lesion formation and soft tissue involvement in metastatic MDA-MB-231 tumor models
Apexbio Technology LLC SAR245409 (XL765) 1349796-36-6 10mM (in 1mL DMSO)
SAR245409 (XL765 CAS 1349796-36-6) is a selective dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with high potency against PI3K (IC50 9 nM) It suppresses the PI3K/Akt/mTOR signaling cascade by preventing formation of phosphatidylinositol-3 4 5-triphosphate (PIP3) at the cell membrane and downstream phosphorylation of AKT p70S6 kinase and S6 SAR245409 demonstrates antitumor activity in cancer models exhibiting genetic alterations in PI3K pathways enhancing growth suppression and apoptosis It is commonly employed in preclinical studies evaluating PI3K/mTOR-targeted approaches in cancer therapy
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide puriss.1L
Dimethyl sulfoxide (DMSO) is a polar solvent. DMSO activated by electrophile (oxalyl chloride) has been used to oxidize various alcohols (primary secondary allylic benzylic hindered and bicyclic). Carbonyl compounds are formed as reaction products. It has been proposed as an alternate solvent for methyl cellosolve for use in ninhydrin reaction due to its high stability.
Apexbio Technology LLC Tipifarnib (Zarnestra) 192185-72-1 10mM (in 1mL DMSO)
Tipifarnib (Zarnestra CAS 192185-72-1) is an orally bioavailable imidazole quinolinone derivative specifically designed as a non-peptidomimetic inhibitor of the enzyme farnesyltransferase (FTase) FTase catalyzes the farnesylation of proteins essential for tumor cell proliferation and survival By selectively blocking FTase activity Tipifarnib disrupts downstream signaling pathways suppressing cellular proliferation and inducing apoptosis across diverse cancer cell types notably acute myeloid leukemia (AML) and multiple myeloma (MM) In preclinical models Tipifarnib demonstrates antiproliferative and pro-apoptotic activities supporting its utility in targeted cancer therapy research
Apexbio Technology LLC E-64 66701-25-5 10mM (in 1mL DMSO)
E-64 is a selective inhibitor targeting cysteine proteases isolated originally from Aspergillus cultures Structurally classified as an L-trans-epoxysuccinyl peptide it irreversibly inhibits proteases such as papain ficin and bromelain by covalent binding to the active-site cysteine residue Its inhibitory activity additionally extends to mammalian cysteine proteases including cathepsins B H and L as well as calcium-dependent protease calpain with reported IC50 values ranging approximately between 10-100 nM depending on specific enzyme assays and conditions In research laboratories E-64 is primarily utilized for mechanistic studies active-site titration assays and quantitative evaluation of cysteine protease concentrations and enzyme kinetics
Apexbio Technology LLC Baicalein 491-67-8 10mM (in 1mL DMSO)
Baicalein is a natural flavonoid compound extracted from the medicinal herb Scutellaria baicalensis known to function as an inhibitor of lipoxygenase enzymes It selectively inhibits the 12-lipoxygenase (12-LOX) mediated metabolic pathway involved in arachidonic acid metabolism subsequently modulating inflammatory responses and cell proliferation signaling Baicalein demonstrates bioactivity as reflected by reported IC50 values typically ranging from 0 6 M to 2 5 M against purified human platelet 12-LOX enzyme It is utilized in biomedical research primarily to study inflammation pathways tumor cell proliferation processes and mechanisms underlying apoptosis induction
Apexbio Technology LLC Azacyclonol 115-46-8 10mM (in 1mL DMSO)
Azacyclonol (CAS 115-46-8) chemically referred to as -pipradol is a small molecule utilized primarily in neuropharmacological research due to its antipsychotic properties Although the precise molecular mechanism remains incompletely defined Azacyclonol is understood to modulate central neurotransmitter systems influencing pathways associated with psychosis Studies have demonstrated its capacity to reduce hallucinations and mitigate psychotic symptoms positioning it as a valuable investigational tool in psychiatric research and therapeutic exploration of psychosis-related disorders
Apexbio Technology LLC SB 203580 152121-47-6 10mM (in 1mL DMSO)
SB 203580 (CAS 152121-47-6) is a pyridinyl imidazole derivative acting as a selective inhibitor of the p38 mitogen-activated protein kinase (MAPK) It competes with ATP binding at or near the kinase ATP-binding region showing a Ki of 21 nM SB 203580 is also reported to inhibit c-Raf in vitro (IC50 2 mM) Experimental studies indicate that SB 203580 reverses multidrug resistance in L1210/VCR cells by reducing tolerance to vincristine Additionally the compound is instrumental in investigating the p38 MAPK pathway in cellular signaling and ischemic neuroprotection models
Apexbio Technology LLC RG2833 1215493-56-3 10mM (in 1mL DMSO)
RG2833 (CAS 1215493-56-3) is a small-molecule inhibitor targeting histone deacetylase (HDAC) In neuronal cell models RG2833 elevates frataxin (FXN) mRNA and protein expression by modifying epigenetic regulation at the FXN locus Studies conducted on peripheral blood mononuclear cells (PBMCs) from patients demonstrated reduced HDAC activity enhanced histone H3 lysine 9 acetylation and elevated FXN mRNA levels upon RG2833 treatment Research utilizing induced pluripotent stem cell (iPSC)-derived neuronal cultures further supports HDAC inhibition as the mechanism underlying RG2833-mediated FXN upregulation This molecule is primarily explored for epigenetic studies in Friedreich s ataxia research