Dimethyl Sulfoxide
Apexbio Technology LLC E 64d 88321-09-9 10mM (in 1mL DMSO)
E-64d is a membrane-permeable cysteine protease inhibitor derived from E-64c acting via covalent modification of the proteolytic active site thiol group It demonstrates inhibitory activity primarily against calpain a calcium-dependent cysteine protease involved in diverse cellular processes E-64d readily penetrates intact cells allowing researchers to inhibit intracellular protease activity without disruption In intact platelet models short incubation with E-64d results in persistent suppression of calpain activity even after removal of extracellular inhibitor by washing Experimentally it is commonly utilized to investigate calpain s role in physiological and pathological events particularly in platelets and cellular apoptosis pathways The typical reported IC50 value of E-64d against calpain is approximately 0 5 1 M
Cayman Chemical PerphenazIn SulfoxIde 25mg
An active metabolite of perphenazine; selectively binds to dopamine D2 and α1-ARs over α2-ARs (Kis= 5.9, 24, and 683 nM, respectively) in rat brain; increases thrombin-induced increases in phosphatidylinositol levels in isolated human platelets at 5 µM
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide anhydrous, 99.9, 67-68-5, MFCD00002089
Dimethyl sulfoxide anhydrous, 99.9
Apexbio Technology LLC Clofazimine 2030-63-9 10mM (in 1mL DMSO)
Clofazimine is a rhimophenazine compound with demonstrated antimicrobial and anti-inflammatory properties commonly utilized in biomedical research related to tuberculosis treatment and drug-resistance studies It functions primarily through the intercalation into bacterial DNA interfering with microbial DNA replication and transcription processes Furthermore it may induce bacterial phospholipid membrane disruption and modulate inflammatory responses Experimental studies report IC50 values in the micromolar range against Mycobacterium tuberculosis strains Clofazimine is frequently employed as a reference compound in antimicrobial assays mechanistic studies on DNA-targeting agents and evaluations of cellular inflammatory pathways within infectious disease model systems
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 99.9% | 78.13 g/mol | C2H6OS | 50mL
Dimethyl sulfoxide cryoprotectant vitrification agent (DMSO cryoprotectant vitrification agent) is a biochemical reagent that can be used as a biological material or organic compound for life science related research[1] This product has been sterilized and has no endotoxin It can be used for long-term cell cryopreservation and will not affect the normal growth of cells
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide puriss.
Dimethyl sulfoxide (DMSO) is a polar solvent. DMSO activated by electrophile (oxalyl chloride) has been used to oxidize various alcohols (primary secondary allylic benzylic hindered and bicyclic). Carbonyl compounds are formed as reaction products. It has been proposed as an alternate solvent for methyl cellosolve for use in ninhydrin reaction due to its high stability.
Apexbio Technology LLC Roscovitine (Seliciclib,CYC202) 186692-46-6 10mM (in 1mL DMSO)
Roscovitine (Seliciclib CYC202 CAS number 186692-46-6) is a selective inhibitor of cyclin-dependent kinases (CDKs) It targets cdc2 (CDK1/cyclin B) CDK2 (CDK2/cyclin A and CDK2/cyclin E) and CDK5 (CDK5/p35) with reported IC50 values of 0 65 M 0 7 M 0 7 M and 0 16 M respectively Additionally roscovitine inhibits extracellular signal-regulated kinases Erk1 and Erk2 displaying IC50 values of 34 M and 14 M respectively In cellular studies roscovitine has been shown to delay or halt transitions during early mitosis specifically preventing cell progression from prophase to metaphase as observed in Xenopus oocyte maturation induced by progesterone Due to its distinct inhibitory profile roscovitine is commonly utilized in research examining cell cycle regulation and kinase signaling pathways relevant to oncology
Apexbio Technology LLC AICAR 10mM (in 1mL DMSO)
A8184 is a small molecule developed primarily as a biomedical research tool It functions through modulation of specific cellular signaling pathways implicated in disease states enabling researchers to probe biological targets and cellular mechanisms By influencing these pathways A8184 provides a methodological approach for dissecting cellular responses and clarifying mechanisms involved in pathological conditions This compound is suited for controlled in vitro studies aimed at elucidating disease pathways and evaluating potential therapeutic avenues in biomedical research contexts
Apexbio Technology LLC GSK-923295 1088965-37-0 10mM (in 1mL DMSO)
GSK-923295 (CAS 1088965-37-0) is a highly potent inhibitor targeting the centromere-associated protein E (CENP-E) a kinesin motor protein essential for proper chromosome alignment and progression from metaphase to anaphase during cell division By blocking microtubule-stimulated ATPase activity of CENP-E GSK-923295 stabilizes an ATP-bound intermediate resulting in significantly reduced enzymatic function (IC50 3 2 nM) In cellular models GSK-923295 induces mitotic arrest with morphological changes similar to CENP-E knockdown In mouse xenograft models using Colo205 colon carcinoma cells administration of GSK-923295 leads to tumor growth inhibition and increased apoptosis supporting its utility in cancer research